Effects of 5-Methyltetrahydrofolate and Vitamin B12 Supplemetation on Red Cell Membrane in Children With Cystic Fibrosis

• Register: ClinicalTrials.gov
• Last refreshed on: 19 February 2015
• Main ID: NCT00730509
• Date of registration: 04/08/2008
• Prospective Registration: No
• Primary sponsor: Universita di Verona
• Public title: Effects of 5-Methyltetrahydrofolate and Vitamin B12 Supplemetation on Red Cell Membrane in Children With Cystic Fibrosis
• Scientific title: Preliminary Evidences of Active Form of Folic Acid and Vitamin B12 Supplementation to Ameliorate Cell Membrane in Children With Cystic Fibrosis
• Date of first enrolment: April 2004
• Target sample size: 31
• Recruitment status: Completed
• URL: http://clinicaltrials.gov/show/NCT00730509
• Study type: Interventional
• Study design: Intervention Model: Single Group Assignment, Masking: Open Label
• Phase: N/A

Countries of recruitment

Italy

Contacts

• Name: Lisa M. Bambara, MD
• Affiliation: Verona University

Key inclusion & exclusion criteria

Inclusion Criteria:

- cystic fibrosis

Exclusion Criteria:

- diabetes

- chronic infections of the airways

- regular antibiotics intake



Age minimum: 3 Years
Age maximum: 8 Years
Gender: Both

Health Condition(s) or Problem(s) studied

Cystic Fibrosis

Intervention(s)

Dietary Supplement: 5-methyltetrahydrofolate and vitamin B12

Primary Outcome(s)

We evaluated membrane protein oxidative damage of red cells [Time Frame: 6 months]

Secondary Outcome(s)

we evaluated cation transport pathways of red cells [Time Frame: 6 months]

Secondary ID(s)

UNIVR_REUM_01

Source(s) of Monetary Support

Please refer to primary and secondary sponsors