World Health Organization site
Skip Navigation Links

Please fill this short user satisfaction survey


Main
Note: This record shows only 22 elements of the WHO Trial Registration Data Set. To view changes that have been made to the source record, or for additional information about this trial, click on the URL below to go to the source record in the primary register.
Register: ClinicalTrials.gov
Last refreshed on: 8 November 2021
Main ID:  NCT00000945
Date of registration: 02/11/1999
Prospective Registration: No
Primary sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Public title: A Study to Evaluate the Use of Cidofovir (an Experimental Drug) for the Treatment of Progressive Multifocal Leukoencephalopathy (PML) in AIDS Patients
Scientific title: A Pilot Study of the Effect of Cidofovir for the Treatment of Progressive Multifocal Leukoencephalopathy (PML) in Subjects With Acquired Immunodeficiency Syndrome (AIDS)
Date of first enrolment: May 1999
Target sample size: 24
Recruitment status: Completed
URL:  https://clinicaltrials.gov/show/NCT00000945
Study type:  Interventional
Study design:  Primary purpose: Treatment.  
Phase:  N/A
Countries of recruitment
United States
Contacts
Name:     Marra CM
Address: 
Telephone:
Email:
Affiliation: 
Name:     Barker DE
Address: 
Telephone:
Email:
Affiliation: 
Key inclusion & exclusion criteria

Inclusion Criteria

You may be eligible for this study if you:

- Are HIV-positive.

- Have had symptoms of PML for no more than 90 days before study entry, or have had
abnormal neurological exams related to PML.

- Have negative tests for bacterial or fungal infections.

- Agree to practice abstinence or use effective methods of birth control during the
study.

- Are at least 18 years old.

- Have a life expectancy of at least 6 months.

Exclusion Criteria

You will not be eligible for this study if you:

- Have a history of uveitis.

- Are allergic to sulfa drugs or probenecid.

- Have had active opportunistic infections other than Kaposi's sarcoma within 30 days
before study entry.

- Have sickle cell anemia or trait.

- Are pregnant or breast-feeding.



Age minimum: 18 Years
Age maximum: N/A
Gender: All
Health Condition(s) or Problem(s) studied
HIV Infections
Leukoencephalopathy, Progressive Multifocal
Intervention(s)
Drug: Cidofovir
Drug: Probenecid
Primary Outcome(s)
Secondary Outcome(s)
Secondary ID(s)
ACTG 363
11327
Source(s) of Monetary Support
Please refer to primary and secondary sponsors
Secondary Sponsor(s)
Ethics review
Results
Results available:
Date Posted:
Date Completed:
URL:
Disclaimer: Trials posted on this search portal are not endorsed by WHO, but are provided as a service to our users. In no event shall the World Health Organization be liable for any damages arising from the use of the information linked to in this section. None of the information obtained through use of the search portal should in any way be used in clinical care without consulting a physician or licensed health professional. WHO is not responsible for the accuracy, completeness and/or use made of the content displayed for any trial record.
Copyright - World Health Organization - Version 3.6 - Version history Please fill this short user satisfaction survey